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Review
. 2017 Jan;15(1):13-17.
doi: 10.1176/appi.focus.20160029. Epub 2017 Jan 11.

Alzheimer's Disease: An Overview of Recent Developments and a Look to the Future

Alice Uflacker  1 , P Murali Doraiswamy  1
Affiliations
Review

Alzheimer's Disease: An Overview of Recent Developments and a Look to the Future

Alice Uflacker et al. Focus (Am Psychiatr Publ). 2017 Jan.

Abstract

Alzheimer's disease is a major public health concern, affecting an estimated 40 million people worldwide. Over the past few years, several new diagnostic tests and new diagnostic nomenclatures have emerged, and more than 70 disease-modifying agents are in clinical trials. Naturalistic studies that include biomarkers-such as genomics, metabolomics, and imaging-have yielded additional insights into disease mechanisms and timelines of preclinical disease onset. This article reviews recent developments in epidemiology, diagnostic criteria, and diagnostic tests; provides updates on symptomatic therapies, ongoing prevention trials, and neuropsychiatric symptom treatment options; and ends with a discussion on prospects for a cure.

Keywords: Dementia-Alzheimer’s Disease.

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References

    1. World Alzheimer Report 2015: The Global Impact of Dementia. London, Alzheimer’s Disease International, 2015.
    1. Scheltens P, Blennow K, Breteler MMB, et al. : Alzheimer’s disease. Lancet 2016; 388:505–517 - PubMed
    1. Kim YJ, Han JW, So YS, et al. : Prevalence and trends of dementia in Korea: a systematic review and meta-analysis. J Korean Med Sci 2014; 29:903–912 - PMC - PubMed
    1. Yuan J, Zhang Z, Wen H, et al. : Incidence of dementia and subtypes: a cohort study in four regions in China. Alzheimers Dement 2016; 12:262–271 - PubMed
    1. Sperling RA, Aisen PS, Beckett LA, et al. : Toward defining the preclinical stages of Alzheimer’s disease: recommendations from the National Institute on Aging–Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 2011; 7:280–292 - PMC - PubMed

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