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Case Reports
. 1988 Dec;33(12):1621-5.
doi: 10.1007/BF01535955.

Blood exchange and transfusion therapy for acute cholestasis in protoporphyria

H J van Wijk  1 , J van Hattum, H Baart de la Faille, J W van den Berg, A Edixhoven-Bosdijk, J H Wilson
Affiliations
Case Reports

Blood exchange and transfusion therapy for acute cholestasis in protoporphyria

H J van Wijk et al. Dig Dis Sci. 1988 Dec.

Abstract

Acute cholestasis is a rare complication of EPP with a high mortality rate despite extensive treatment with corticosteroids, cholestyramine, and antioxidants. A single survivor, reported in the literature, was treated with blood exchange transfusions. We treated two EPP patients with blood exchange and additional blood transfusions which resulted in full clinical and biochemical recovery from the cholestasis and accompanying hepatitis. Recurrences of the cholestasis and hepatitis could repeatedly be corrected by additional blood transfusions.

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