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. 2020 Jan 24;11(1):11-19.
doi: 10.5306/wjco.v11.i1.11.

Predictors of distant metastasis in acinic cell carcinoma of the parotid gland

Syed Ahmed Ali  1 , Kevin J Kovatch  1 , Jonah Yousif  1 , Sonali Gupta  1 , Andrew J Rosko  1 , Matthew E Spector  2
Affiliations

Predictors of distant metastasis in acinic cell carcinoma of the parotid gland

Syed Ahmed Ali et al. World J Clin Oncol. .

Abstract

Background: AiCC is a primarily indolent disease process. Our aim with this study is to determine characteristics consistent with rapidly progressive AiCC of the parotid gland.

Aim: To report on patients with metastatic lung disease from AiCC and potential correlative factors.

Methods: Single-institution retrospective review of patients treated at the University of Michigan between 2000 and 2017. Univariate analyses were performed.

Results: A total of 55 patients were identified. There were 6 patients (10.9%) with primary AiCC of the parotid gland who developed lung metastases. The mean age at diagnosis for patients with lung metastases was 57.8 years of age, in comparison to 40.2 years for those without metastases (P = 0.064). All 6 of the patients with lung metastases demonstrated gross perineural invasion intraoperatively, in comparison to none of those in the non-lung metastases cohort. Worse disease-free and overall survival were significantly associated with gross perineural invasion, high-grade differentiation, and T4 classification (P < 0.001).

Conclusion: AiCC of the parotid gland is viewed as a low-grade neoplasm with good curative outcomes and low likelihood of metastasis. With metastasis, however, it does exhibit a tendency to spread to the lungs. These patients thereby comprise a unique and understudied patient population. In this retrospective study, factors that have been shown to be statistically significant in association with worse disease-free survival and overall survival include presence of gross facial nerve invasion, higher T-classification, and high-grade disease.

Keywords: Acinic cell carcinoma; Distant metastases; Facial nerve; Parotid gland; Perineural invasion.

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Conflict of interest statement

Conflict-of-interest statement: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Disease-free survival (time in months) by gross facial nerve invasion, grade, and T-stage. A: Gross facial nerve invasion; B: Grade; C: T-stage.
Figure 2
Figure 2
Hematoxylin-eosin staining of high-grade acinic cell carcinoma with perineural invasion. Images are magnified at 400× (40× objective lens × 10× ocular lens). Scale bar represents 50 µm.
Figure 3
Figure 3
Hematoxylin-eosin staining of low-grade acinic cell carcinoma. Images are magnified at 400× (40× objective lens × 10× ocular lens). Scale bar represents 50 µm.
See this image and copyright information in PMC

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