Co-occurrence of DNMT3A, NPM1, FLT3 mutations identifies a subset of acute myeloid leukemia with adverse prognosis

Matheus F Bezerra^{1

2}, Aleide S Lima³, Maria-Riera Piqué-Borràs⁴, Douglas R Silveira^{5

6}, Juan L Coelho-Silva^{3

7}, Diego A Pereira-Martins^{3

7}, Isabel Weinhäuser⁷, Pedro L Franca-Neto³, Lynn Quek^{8

9}, Anna Corby⁹, Mayara M Oliveira³, Marinus M Lima³, Reijane A de Assis¹⁰, Paula de Melo Campos¹¹, Bruno K Duarte^{11

12}, Israel Bendit⁵, Vanderson Rocha⁵, Eduardo M Rego⁵, Fabiola Traina⁷, Sara T Saad^{11

12}, Eduardo I Beltrão¹³, Marcos A Bezerra³, Antonio R Lucena-Araujo³

Affiliations

¹ Keizo Asami Immunopathology Laboratory, Federal University of Pernambuco, Recife, Brazil.
² Aggeu Magalhães Institute, Oswaldo Cruz Foundation, Recife, Brazil.
³ Department of Genetics, Federal University of Pernambuco, Recife, Brazil.
⁴ Department of Biomedicine, University of Basel, Basel, Switzerland.
⁵ Hematology Division, LIM31, Faculdade de Medicina, University of São Paulo, São Paulo, Brazil.
⁶ Hematology Department, AC Camargo Cancer Center, São Paulo, Brazil.
⁷ Department of Internal Medicine, Medical School of Ribeirão Preto, Ribeirão Preto, Brazil.
⁸ Department of Hematology, Oxford University Hospitals National Health Service (NHS) Foundation Trust, Oxford, United Kingdom.
⁹ Medical Research Council (MRC) Molecular Hematology Unit, Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, Oxford, United Kingdom.
¹⁰ Department of Internal Medicine, Hematology and Hemotherapy Foundation of Pernambuco, Recife, Brazil.
¹¹ Hematology and Transfusion Medicine Center and.
¹² Department of Internal Medicine, University of Campinas, Campinas, São Paulo, Brazil; and.
¹³ Department of Biochemistry, Federal University of Pernambuco, Recife, Brazil.

Free article

Matheus F Bezerra et al. Blood. 2020.

Free article

. 2020 Mar 12;135(11):870-875.

doi: 10.1182/blood.2019003339.

¹ Keizo Asami Immunopathology Laboratory, Federal University of Pernambuco, Recife, Brazil.
² Aggeu Magalhães Institute, Oswaldo Cruz Foundation, Recife, Brazil.
³ Department of Genetics, Federal University of Pernambuco, Recife, Brazil.
⁴ Department of Biomedicine, University of Basel, Basel, Switzerland.
⁵ Hematology Division, LIM31, Faculdade de Medicina, University of São Paulo, São Paulo, Brazil.
⁶ Hematology Department, AC Camargo Cancer Center, São Paulo, Brazil.
⁷ Department of Internal Medicine, Medical School of Ribeirão Preto, Ribeirão Preto, Brazil.
⁸ Department of Hematology, Oxford University Hospitals National Health Service (NHS) Foundation Trust, Oxford, United Kingdom.
⁹ Medical Research Council (MRC) Molecular Hematology Unit, Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, Oxford, United Kingdom.
¹⁰ Department of Internal Medicine, Hematology and Hemotherapy Foundation of Pernambuco, Recife, Brazil.
¹¹ Hematology and Transfusion Medicine Center and.
¹² Department of Internal Medicine, University of Campinas, Campinas, São Paulo, Brazil; and.
¹³ Department of Biochemistry, Federal University of Pernambuco, Recife, Brazil.

No abstract available

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