Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Apr;22(2):e13249.
doi: 10.1111/tid.13249. Epub 2020 Feb 10.

Salvage heart transplantation for Mycoplasma hominis prosthetic valve endocarditis: A case report and review of the literature

Filippo Givone  1 , Maddalena Peghin  1 , Igor Vendramin  2 , Silvia Carletti  3 , Vincenzo Tursi  2 , Renée Pasciuta  3 , Ugolino Livi  2 , Matteo Bassetti  1   4
Affiliations
Review

Salvage heart transplantation for Mycoplasma hominis prosthetic valve endocarditis: A case report and review of the literature

Filippo Givone et al. Transpl Infect Dis. 2020 Apr.

Abstract

Heart transplantation (HT) has been rarely performed in patients with infective endocarditis (IE) and is considered a "last resort" procedure. Orthotropic HT with bicaval technique was performed in a man with culture-negative endocarditis. Mycoplasma hominis was later detected using 16S ribosomal DNA PCR from surgically removed valve tissue. Literature review and previous results are summarized. HT may be considered as salvage treatment in selected patients with intractable IE. In cases when there is no growth in culture, 16S ribosomal DNA PCR sequencing can be used to identify the pathogen in excised valvular tissue. Mycoplasma spp. is extremely uncommon and difficult to diagnose cause of infective endocarditis (IE). There are no proposed or defined criteria for heart transplantation (HT) in patients with refractory IE, and HT has been rarely performed in this setting. We report a case of M hominis prosthetic valve endocarditis diagnosed by 16S ribosomal DNA PCR in a patient who underwent a salvage HT. We reviewed in the literature other cases of IE caused by Mycoplasma spp.

Keywords: Mycoplasma; infective endocarditis; salvage heart transplantation.

PubMed Disclaimer

References

REFERENCES

    1. Fenollar F, Gauduchon V, Casalta JP, Lepidi H, Vandenesch F, Raoult D. Mycoplasma endocarditis: two case reports and a review. Clin Infect Dis. 2004;38(3):e21-e24.
    1. Murphy KM, Vikram HR. Heart transplantation for infective endocarditis: viable option for a limited few? Transpl Infect Dis. 2019;21(1):e13006.
    1. Prendergast BD. The changing face of infective endocarditis. Heart. 2006;92(7):879-885.
    1. Millar BC, Habib G, Moore JE. New diagnostic approaches in infective endocarditis. Heart. 2016;102(10):796-807.
    1. Fournier PE, Gouriet F, Casalta JP, et al. Blood culture-negative endocarditis: improving the diagnostic yield using new diagnostic tools. Medicine. 2017;96(47):e8392.

MeSH terms

LinkOut - more resources