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. 2020 Jun;34(6):e23211.
doi: 10.1002/jcla.23211. Epub 2020 Jan 24.

Hematological factors associated with immunity, inflammation, and metabolism in patients with systemic lupus erythematosus: Data from a Zhuang cohort in Southwest China

Xiaoxia Lao  1 , Liping Ma  1 , Qingwei Ma  1 , Qiaorong Ma  1 , Zhige Yang  1 , Lingxiao Guo  1 , Wenzheng Nong  2
Affiliations

Hematological factors associated with immunity, inflammation, and metabolism in patients with systemic lupus erythematosus: Data from a Zhuang cohort in Southwest China

Xiaoxia Lao et al. J Clin Lab Anal. 2020 Jun.

Abstract

Introduction: Hematological parameters play important role in multiple diseases. This study was to investigate the possible association of the routine hematological parameters involved in immunity, inflammation, and metabolism with systemic lupus erythematosus (SLE) in patients of Zhuang ethnicity in Guangxi, southwest China.

Methods: The medical records of 195 Zhuang SLE patients between January 2013 and November 2018 were retrospectively reviewed. Random forest algorithm and multivariate logistic regression were used to identify the feature hematological parameters in patients with SLE. Association rules were explored between each parameter and immunity- (IgG, IgA, IgM, C3, and C4), inflammation- (ESR, hs-CRP, and CAR), and metabolism- (TG, TC, HDL-C, LDL-C, TP, PA, ALB, and UA) related indexes.

Results: Random forest algorithm and logistic regression analysis showed that neutrophil-to-lymphocyte ratio (NLR), red blood cell distribution width (RDW), and platelet-to-lymphocyte ratio (PLR) were the feature parameters for distinguishing SLE patients from healthy controls. According to the ROC curves, the optimal cutoff values to predict SLE were 1.98 for NLR, 13.35 for RDW, and 145.64 for PLR. Association rule analysis showed that NLR was strongly associated with C3, hs-CRP, TG, ALB, and UA; RDW was strongly associated with C3, C4, hs-CRP, TG, and ALB; PLR was strongly associated with IgG, hs-CRP, HDL-C, and UA.

Conclusions: Neutrophil-to-lymphocyte ratio, RDW, and PLR may serve as effective predictors of dysregulation in immunity, inflammation, and metabolism. These three indicators may be potential for cardiovascular risk assessment in Zhuang SLE patients in southwest China.

Keywords: association rule; hematological parameters; immunity; inflammation; metabolism; systemic lupus erythematosus.

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Figures

Figure 1
Figure 1
Comparison of NLR (neutrophils‐to‐lymphocytes ratio), RDW (red blood cell distribution width), and PLR (platelet‐to‐lymphocyte ratio) levels in SLE patients and healthy controls
Figure 2
Figure 2
Multi‐dimensional scaling graph of the hematological parameters. The abscissa and longitudinal coordinates indicate two dimensionalities; the red dogs and blue dots indicate SLE and healthy controls, respectively
Figure 3
Figure 3
Comparison of Mean Decrease Gini values for hematological parameters in systemic lupus erythematosus patients
Figure 4
Figure 4
ROC curves of neutrophil‐to‐lymphocyte ratio, red blood cell distribution width, and platelet‐to‐lymphocyte ratio for differentiating systemic lupus erythematosus patients
See this image and copyright information in PMC

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