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Comment
. 2020 Jan 23;180(2):218-220.
doi: 10.1016/j.cell.2019.12.034.

Bacteriophage Prevents Alcoholic Liver Disease

Melis Çolakoğlu  1 , Jing Xue  1 , Mirko Trajkovski  2
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Free article
Comment

Bacteriophage Prevents Alcoholic Liver Disease

Melis Çolakoğlu et al. Cell. .
Free article

Abstract

Alcoholic hepatitis is a severe alcohol-associated liver disease with minimal treatment options. A recent study by Duan et al. uncovers that the exotoxin-secreting gut bacterium Enterococcus faecalis is a critical contributor to alcoholic hepatitis. This bacterium can now be eliminated with a bacteriophage, suggesting a new way to treat this life-threatening disease.

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  • Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease.
    Duan Y, Llorente C, Lang S, Brandl K, Chu H, Jiang L, White RC, Clarke TH, Nguyen K, Torralba M, Shao Y, Liu J, Hernandez-Morales A, Lessor L, Rahman IR, Miyamoto Y, Ly M, Gao B, Sun W, Kiesel R, Hutmacher F, Lee S, Ventura-Cots M, Bosques-Padilla F, Verna EC, Abraldes JG, Brown RS Jr, Vargas V, Altamirano J, Caballería J, Shawcross DL, Ho SB, Louvet A, Lucey MR, Mathurin P, Garcia-Tsao G, Bataller R, Tu XM, Eckmann L, van der Donk WA, Young R, Lawley TD, Stärkel P, Pride D, Fouts DE, Schnabl B. Duan Y, et al. Nature. 2019 Nov;575(7783):505-511. doi: 10.1038/s41586-019-1742-x. Epub 2019 Nov 13. Nature. 2019. PMID: 31723265 Free PMC article.

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