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Review
. 2020 Jan 23;25(3):493.
doi: 10.3390/molecules25030493.

Biological Activities of Gedunin-A Limonoid from the Meliaceae Family

Teresa M Braga  1 , Lídia Rocha  1 , Tsz Yan Chung  1 , Rita F Oliveira  1 , Cláudia Pinho  1 , Ana I Oliveira  1 , Joaquim Morgado  2   3 , Agostinho Cruz  1
Affiliations
Review

Biological Activities of Gedunin-A Limonoid from the Meliaceae Family

Teresa M Braga et al. Molecules. .

Abstract

Gedunin is an important limonoid present in several genera of the Meliaceae family, mainly in seeds. Several biological activities have been attributed to gedunin, including antibacterial, insecticidal, antimalarial, antiallergic, anti-inflammatory, anticancer, and neuroprotective effects. The discovery of gedunin as a heat shock protein (Hsp) inhibitor represented a very important landmark for its application as a biological therapeutic agent. The current study is a critical literature review based on the several biological activities so far described for gedunin, its therapeutic effect on some human diseases, and future directions of research for this natural compound.

Keywords: Meliaceae family; bioactive compound; biological activity; gedunin; limonoid.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Biological activities of gedunin.
Figure 2
Figure 2
Chemical structure of gedunin: (a) Two-dimensional structural formula and (b) three-dimensional model; (c) Biosynthesis pathway of gedunin (adapted from Narender et al. [12] and Aarthy et al. [15]). ChemSketch software was used to create all chemical structures.
See this image and copyright information in PMC

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