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Comparative Study
. 1988 Nov;72(2):257-63.
doi: 10.1016/0016-6480(88)90208-0.

A gonial mitosis-stimulating factor in cerebral ganglia and hemolymph of the marine mussel Mytilus edulis L

M Mathieu  1 , F Lenoir, I Robbins
Affiliations
Comparative Study

A gonial mitosis-stimulating factor in cerebral ganglia and hemolymph of the marine mussel Mytilus edulis L

M Mathieu et al. Gen Comp Endocrinol. 1988 Nov.

Abstract

A gonial mitosis-stimulating factor produced by the cerebral ganglia of the mussel Mytilus edulis has been demonstrated. This factor induces an increase of [3H]thymidine incorporation in the DNA of isolated mantle cells. Dose-response data are obtained with the methanol phase of an acidic ganglia extract. The rate of [3H]thymidine incorporation is compared with aspartate transcarbamylase specific activity, another bioassay previously described to estimate mitotic activity. This heat-stable mitogenic factor appears to have a molecular weight of less than 5000 Da. A gonial mitogenic factor is also found in the hemolymph and circulatory cells.

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