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Comment
. 2020 Feb;140(2):278-281.
doi: 10.1016/j.jid.2019.07.683.

Spherical Nucleic Acids as Emerging Topical Therapeutics: A Focus on Psoriasis

Emrullah Korkmaz  1 , Louis D Falo Jr  2
Affiliations
Comment

Spherical Nucleic Acids as Emerging Topical Therapeutics: A Focus on Psoriasis

Emrullah Korkmaz et al. J Invest Dermatol. 2020 Feb.

Abstract

Systemically delivered targeted biologics have revolutionized the treatment of moderate-to-severe psoriasis. For milder forms of psoriasis, topical therapies, primarily corticosteroids, remain the mainstay of treatment to reduce the risks and off-target side effects associated with systemic therapies. Most newly developed biologics, including monoclonal antibodies, are structurally complex and are unable to penetrate the skin barrier. Recently developed liposomal spherical nucleic acids overcome this barrier and enable topical delivery of antisense oligonucleotides capable of specifically targeting inflammatory pathways underlying psoriasis pathogenesis.

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Conflict of interest statement

Conflict of Interest

EK states no conflict of interest. LDF is a scientific advisor for and holds an equity position in BrainStage and SkinJect.

Figures

Figure 1.
Figure 1.
Topical liposomal spherical nucleic acid (L-SNA) treatment of psoriasis. Topically applied L-SNAs delivering IL-17RA antisense oligonucleotides are internalized by IL-17R expressing keratinocytes in psoriatic skin, reducing IL-17R expression and the expression of IL-17 dependent proinflammatory genes involved in psoriasis pathogenesis.
See this image and copyright information in PMC

Comment on

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