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. 2020 Mar;41(3):142-146.
doi: 10.1016/j.tips.2019.12.006. Epub 2020 Jan 21.

Identifying Missing Biosynthesis Enzymes of Plant Natural Products

Thomas Dugé de Bernonville  1 , Nicolas Papon  2 , Marc Clastre  1 , Sarah E O'Connor  3 , Vincent Courdavault  4
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Free article

Identifying Missing Biosynthesis Enzymes of Plant Natural Products

Thomas Dugé de Bernonville et al. Trends Pharmacol Sci. 2020 Mar.
Free article

Abstract

Elucidating plant-specialized biosynthetic pathways has always constituted a laborious task, notably for natural products with high pharmaceutical values. Here, we discuss emerging omics-based strategies that facilitate the identification of genes from these complex metabolic pathways, paving the way to engineered supplies of these compounds through synthetic biology approaches.

Keywords: RNA-seq; coexpression network; gene identification; specialized metabolites; whole genome sequencing.

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