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Comment
. 2020 Mar;10(3):OF2.
doi: 10.1158/2159-8290.CD-RW2020-013. Epub 2020 Jan 24.

YAP Mediates EGFR Inhibitor-Induced Dormancy in EGFR-Mutant Cancer

No authors listed
Comment

YAP Mediates EGFR Inhibitor-Induced Dormancy in EGFR-Mutant Cancer

No authors listed. Cancer Discov. 2020 Mar.

Abstract

YAP activation mediates resistance to EGFR and MEK inhibition in EGFR-mutant cancer cells.

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  • Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway.
    Kurppa KJ, Liu Y, To C, Zhang T, Fan M, Vajdi A, Knelson EH, Xie Y, Lim K, Cejas P, Portell A, Lizotte PH, Ficarro SB, Li S, Chen T, Haikala HM, Wang H, Bahcall M, Gao Y, Shalhout S, Boettcher S, Shin BH, Thai T, Wilkens MK, Tillgren ML, Mushajiang M, Xu M, Choi J, Bertram AA, Ebert BL, Beroukhim R, Bandopadhayay P, Awad MM, Gokhale PC, Kirschmeier PT, Marto JA, Camargo FD, Haq R, Paweletz CP, Wong KK, Barbie DA, Long HW, Gray NS, Jänne PA. Kurppa KJ, et al. Cancer Cell. 2020 Jan 13;37(1):104-122.e12. doi: 10.1016/j.ccell.2019.12.006. Cancer Cell. 2020. PMID: 31935369 Free PMC article.