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. 2020 Feb;12(1):13-18.
doi: 10.1007/s12551-020-00612-9. Epub 2020 Jan 24.

Reflections on professor Sir Christopher M. Dobson (1949-2019)

Mireille Dumoulin  1
Affiliations

Reflections on professor Sir Christopher M. Dobson (1949-2019)

Mireille Dumoulin. Biophys Rev. 2020 Feb.

Abstract

I have been invited to summarize my career with an emphasis on the time I spent in the laboratory of Prof Christopher M. Dobson, who sadly passed away on September 8th 2019, and to describe his role as a mentor. I accepted this slightly unusual request as it constitutes a unique way for me to express my deep gratitude and admiration for Chris.

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Figures

Fig. 1
Fig. 1
Professor Christopher Dobson with researchers involved in the I.A.P network working on VHHs and amyloidogenic proteins at the time of the 1-day symposiums on Protein Folding and Stability, organized by Prof. André Matagne in 2005. From left to right: André Matagne, Chris, Mireille Dumoulin, Jean-Marie Frère, Lode Wyns, Els Pardon, Katja Conrath and Erwin De Genst
Fig. 2
Fig. 2
Professor Christopher Dobson when he received his Honoris Causa degree from the University of Liège in 2007
See this image and copyright information in PMC

References

    1. Ahn M, Hagan CL, Bernardo-Gancedo A, De Genst E, Newby FN, Christodoulou J, Dhulesia A, Dumoulin M, Robinson CV, Dobson CM, Kumita JR. The significance of the location of mutations for the native-state dynamics of human lysozyme. Biophys J. 2016;111(11):2358–2367. doi: 10.1016/j.bpj.2016.10.028. - DOI - PMC - PubMed
    1. Buell AK, Dhulesia A, Mossuto MF, Cremades N, Kumita JR, Dumoulin M, Welland ME, Knowles TPJ, Salvatella X, Dobson CM. Population of nonnative states of lysozyme variants drives amyloid fibril formation. J Am Chem Soc. 2011;133(20):7737–7743. doi: 10.1021/ja109620d. - DOI - PMC - PubMed
    1. Canet Denis, Last Alexander M., Tito Paula, Sunde Margaret, Spencer Andrew, Archer David B., Redfield Christina, Robinson Carol V., Dobson Christopher M. Local cooperativity in the unfolding of an amyloidogenic variant of human lysozyme. Nature Structural Biology. 2002;9(4):308–315. doi: 10.1038/nsb768. - DOI - PubMed
    1. Cawez F, Duray E, Hu Y, Vandenameele J, Romão E, Vincke C, Dumoulin M, Galleni M, Muyldermans S, Vandevenne M. Combinatorial design of a nanobody that specifically targets structured RNAs. J Mol Biol. 2018;430(11):1652–1670. doi: 10.1016/j.jmb.2018.03.032. - DOI - PubMed
    1. De Genst E, Chan PH, Pardon E, Hsu STD, Kumita JR, Christodoulou J, Menzer L, Chirgadze DY, Robinson CV, Muyldermans S, Matagne A, Wyns L, Dobson CM, Dumoulin M. A nanobody binding to non-amyloidogenic regions of the protein human lysozyme enhances partial unfolding but inhibits amyloid fibril formation. J Phys Chem B. 2013;117(42):13245–13258. doi: 10.1021/jp403425z. - DOI - PMC - PubMed

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