Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988:(89):121-8.

Approaches to the development of assays for interaction of tobacco-specific nitrosamines with haemoglobin and DNA

S S Hecht  1 , S G Carmella, N Trushin, T E Spratt, P G Foiles, D Hoffmann
Affiliations
  • PMID: 3198194

Approaches to the development of assays for interaction of tobacco-specific nitrosamines with haemoglobin and DNA

S S Hecht et al. IARC Sci Publ. 1988.

Abstract

The tobacco-specific, nicotine-derived nitrosamines 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK) and N'-nitrosonornicotine (NNN) are among the most important carcinogens in tobacco and tobacco smoke. Treatment of Fischer 344 rats with these carcinogens resulted in alkylation of haemoglobin and DNA by the 4-(3-pyridyl)-4-oxobutyl group formed during their metabolism. This alkyl group can be detached from globin or DNA under mild hydrolytic conditions as 4-hydroxy-1-(3-pyridyl)-1-butanone, which appears to be a potentially useful dosimeter for human exposure to, and activation of, tobacco-specific nitrosamines.

PubMed Disclaimer

Publication types