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. 1988:(89):389-95.

Nonselective and selective methods for biological monitoring of exposure to coal-tar products

R P Bos  1 , F J Jongeneelen
Affiliations
  • PMID: 3198226

Nonselective and selective methods for biological monitoring of exposure to coal-tar products

R P Bos et al. IARC Sci Publ. 1988.

Abstract

Biological monitoring of exposure to coal-tar products has been carried out using the nonselective urinary mutagenicity and thioether assays and a selective method for the detection of 1-hydroxypyrene in urine. The sensitivities of the three methods have been compared. In several work environments, no increase that could be related to exposure to coal-tar products was found with the nonselective methods, whereas the levels of 1-hydroxypyrene in urine were enhanced. The applicability of the method for the detection of 1-hydroxypyrene in urine is further demonstrated.

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