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Meta-Analysis
. 2020 Jan;25(1):4-17.
doi: 10.17712/nsj.2020.1.20190037.

The potential role of nutritional components in improving brain function among patients with Alzheimers disease: a meta-analysis of RCT studies

Tarfa Albrahim  1
Affiliations
Meta-Analysis

The potential role of nutritional components in improving brain function among patients with Alzheimers disease: a meta-analysis of RCT studies

Tarfa Albrahim. Neurosciences (Riyadh). 2020 Jan.

Abstract

Objective: To find out the potential role of nutritional components in improving brain function among patients with Alzheimer`s disease (AD).

Methods: The correlation between nutrition and cerebral function in cases of AD has been the focus of 19 prospective randomised controlled trials (RCTs) with a combined research sample of 2297 patients. These RCTs are subject to systematic review and meta-analysis in the current paper RESULTS: Findings showed that chain-free secondary saturated fatty acids (SFA) and trans fatty acids (TFA) occurred in higher concentrations in AD patients` brains than in controls. Furthermore, neuroinflammation was caused by remodelling of the lipid membrane and AD patients` cognitive function was impacted by alterations in tyrosine, tryptophan, purine, and tocopherol pathway metabolomics. Moreover, in cases of mild-to-moderate AD, reduction in functionality was induced by administration of alpha-tocopherol for more than 12 months. Consumption of Souvenaid helps in synaptic synthesis, which enhances functional connectivity. Furthermore, consumption of the B vitamins folate, cobalamin and pyridoxine at dosages of 0.8 mg, 0.5 mg and 20 mg per day, respectively, over a period of one year resulted in lower plasma tHcy levels and brain atrophy.

Conclusion: Chain-free SFA and TFA occur in greater amounts in the brains of individuals with AD than in those without AD.

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