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. 2020 Apr;107(4):707-709.
doi: 10.1002/cpt.1763. Epub 2020 Jan 26.

Scientific and Regulatory Considerations for an Ontogeny Knowledge Base for Pediatric Clinical Pharmacology

Gilbert J Burckart  1 , Shirley Seo  1 , Aaron C Pawlyk  2 , Susan K McCune  3 , Lynne P Yao  4 , George P Giacoia  2 , Yaning Wang  1 , Issam Zineh  1
Affiliations

Scientific and Regulatory Considerations for an Ontogeny Knowledge Base for Pediatric Clinical Pharmacology

Gilbert J Burckart et al. Clin Pharmacol Ther. 2020 Apr.

Abstract

Understanding all aspects of developmental biology, or pediatric ontogeny, that affect drug therapy from the fetus to the adolescent child is the holy grail of pediatric scientists and clinical pharmacologists. The scientific community is now close to being able to tie together the vast amount of information collected on pediatric ontogeny over the past 60 years. An organized knowledge base and new tools would allow us to utilize this information effectively in pediatric drug development.

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Conflict of interest statement

CONFLICT OF INTEREST

The authors declared no competing interests for this work. As an Associate Editor for Clinical Pharmacology & Therapeutics, Shirley Seo was not involved in the review or decision process for this paper.

References

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