Concise review of machine perfusion in liver transplantation
- PMID: 31984116
- PMCID: PMC6946625
- DOI: 10.4254/wjh.v12.i1.6
Concise review of machine perfusion in liver transplantation
Abstract
With the advances and clinical growth in liver transplantation over the last four decades the focus on expanding deceased donor organs has been in need of scientific research. In the past ten years several researchers have looked at the domain of machine perfusion as it applies to deceased donor livers. The following review focuses on the clinical trials and recent advances that will likely have the earliest entrance into the clinical arena.
Keywords: Ex vivo perfusion; Ischemia reperfusion; Liver transplantation; Machine perfusion; Organ preservation.
©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Conflict of interest statement
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
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References
-
- Nasralla D, Coussios CC, Mergental H, Akhtar MZ, Butler AJ, Ceresa CDL, Chiocchia V, Dutton SJ, García-Valdecasas JC, Heaton N, Imber C, Jassem W, Jochmans I, Karani J, Knight SR, Kocabayoglu P, Malagò M, Mirza D, Morris PJ, Pallan A, Paul A, Pavel M, Perera MTPR, Pirenne J, Ravikumar R, Russell L, Upponi S, Watson CJE, Weissenbacher A, Ploeg RJ, Friend PJ Consortium for Organ Preservation in Europe. A randomized trial of normothermic preservation in liver transplantation. Nature. 2018;557:50–56. - PubMed
-
- Younossi ZM, Koenig AB, Abdelatif D, Fazel Y, Henry L, Wymer M. Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology. 2016;64:73–84. - PubMed
-
- Quillin RC, 3rd, Guarrera JV. Hypothermic machine perfusion in liver transplantation. Liver Transpl. 2018;24:276–281. - PubMed
-
- Jia JJ, Li JH, Yu H, Nie Y, Jiang L, Li HY, Zhou L, Zheng SS. Machine perfusion for liver transplantation: A concise review of clinical trials. Hepatobiliary Pancreat Dis Int. 2018;17:387–391. - PubMed
-
- Guarrera JV, Henry SD, Samstein B, Odeh-Ramadan R, Kinkhabwala M, Goldstein MJ, Ratner LE, Renz JF, Lee HT, Brown RS, Jr, Emond JC. Hypothermic machine preservation in human liver transplantation: the first clinical series. Am J Transplant. 2010;10:372–381. - PubMed
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