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Review
. 2020 Apr;50(4):e13203.
doi: 10.1111/eci.13203. Epub 2020 Mar 6.

Genetic variations in MicroRNA genes and cancer risk: A field synopsis and meta-analysis

Jae Hyon Park  1 , Gwang Hun Jeong  2 , Kwang Seob Lee  1 , Keum Hwa Lee  3   4   5 , Jin-Soon Suh  6 , Michael Eisenhut  7 , Hans J van der Vliet  8 , Andreas Kronbichler  9 , Brendon Stubbs  10   11   12 , Marco Solmi  13 , Elena Dragioti  14 , Ai Koyanagi  15   16 , Jae Il Shin  3   4   5 , Gabriele Gamerith  17   18
Affiliations
Review

Genetic variations in MicroRNA genes and cancer risk: A field synopsis and meta-analysis

Jae Hyon Park et al. Eur J Clin Invest. 2020 Apr.

Abstract

Background: Cancer risk has been associated with certain gene variations in microRNA (miRNA), but conflicting evidence warrants re-assessing of significant results in meta-analyses. We summarized published meta-analyses that assess the associations between miRNA polymorphism and cancers to show the validity of the findings.

Method: We searched PubMed and investigated the results of meta-analyses published through November 2018. We re-assessed the results based on false-positive report probability (FPRP) to test the noteworthiness of the associations.

Results: Sixty-eight miRNA polymorphisms in 45 meta-analyses associated with cancer were included. Four (7.4%) and sixteen (25.0%) single nucleotide polymorphisms (SNPs) were noteworthy (FPRP < 0.2) at a prior probability of 0.001 for interesting candidate genes and a statistical power to detect an odds ratio (OR) of 1.1 and 1.5, respectively. The four miRNA SNPs noteworthy at an OR of 1.1 were as follows: miR-146a/rs2910164 Cvs.G; miR-27a/rs895819 Cvs.T; miR-423/rs6505162 Cvs.A; and miR-605/rs2043556 Cvs.T. The 16 SNPs noteworthy at an OR of 1.5 include the four genotype comparisons at an OR of 1.1, and the additional 12 genotype comparisons were as follows: miR-196a2/rs11614913 Tvs.C; miR-27a/rs895819 GGvs.AA + AG; miR-196a2/rs11614913 C vs.T; miR-146a/rs2910164 Gvs.C; miR-196a2/rs11614913 Tvs.C; miR-146a/rs2910164 Cvs.G; miR-499/rs3746444 homozygous model; miR-146a/rs2910164 CCvs.GG + GC; miR-499/rs3746444 TCvs.TT; miR-499/rs3746444 GAvs.AA; miR-146a/rs2910164 CCvs.GG; and miR-499/rs3746444 Gvs.A. No association was noteworthy at a prior probability of 0.000001.

Conclusion: Out of 68 published associations of miRNA polymorphisms with cancer, sixteen have shown noteworthiness in our re-assessing meta-analysis. Our findings summarize the results of meta-analyses on the association of cancer with SNPs and underline the importance of interpreting results with caution.

Keywords: FPRP; cancer; gene variant; meta-analysis; microRNA.

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