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. 2020 May;74(5):303-310.
doi: 10.1111/pcn.12983. Epub 2020 Feb 23.

Neuroticism, conscientiousness, and in vivo Alzheimer pathologies measured by amyloid PET and MRI

Min Soo Byun  1 , Joon Hyung Jung  2 , Bo Kyung Sohn  3 , Dahyun Yi  4 , Jun Ho Lee  5 , So Yeon Jeon  6 , Younghwa Lee  7 , Gi Jung Jung  7 , Jun-Young Lee  8 , Yu Kyeong Kim  9 , Seong A Shin  9 , Chul-Ho Sohn  10 , Koung Mi Kang  10 , Dong Young Lee  2   4   7 ; KBASE Research Group
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Free article

Neuroticism, conscientiousness, and in vivo Alzheimer pathologies measured by amyloid PET and MRI

Min Soo Byun et al. Psychiatry Clin Neurosci. 2020 May.
Free article

Abstract

Aim: It has been suggested that personality traits, particularly neuroticism and conscientiousness, are risk factors for Alzheimer's disease (AD) and related cognitive decline. However, the underlying pathological links between personality traits and AD-related cognitive impairments remain unclear. Thus, the present study investigated associations of neuroticism and conscientiousness with in vivo cerebral amyloid-beta (Aβ) burden, AD-signature regional neurodegeneration, and white matter hyperintensities (WMH) in non-demented middle- and old-aged adults.

Methods: A total of 397 non-demented participants underwent comprehensive clinical and neuropsychological assessments, 11 C-labeled Pittsburgh Compound B positron emission tomography, and magnetic resonance imaging. Additionally, the NEO Five-Factor Inventory was administered to both the participants and their informants to measure neuroticism and conscientiousness.

Results: Neither neuroticism nor conscientiousness was associated with cerebral Aβ deposition or WMH. In contrast, higher neuroticism and lower conscientiousness, reported by informants in particular, were significantly associated with reduced AD-signature region cortical thickness. In regards to the direct and indirect effect of each personality on AD-signature region cortical thickness, only the direct effects were found, whereas indirect effects via Aβ deposition or WMH were not.

Conclusion: The present findings suggest that amyloid-independent regional neurodegeneration might underlie relations of neuroticism and conscientiousness with AD.

Keywords: Alzheimer's disease; beta-amyloid; conscientiousness; neurodegeneration; neuroticism.

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References

    1. Matthews G, Deary IJ, Whiteman MC. Personality Traits. Cambridge University Press, Cambridge, 2009.
    1. Terracciano A, Sutin AR, An Y et al. Personality and risk of Alzheimer's disease: New data and meta-analysis. Alzheimers Dement. 2014; 10: 179-186.
    1. Low LF, Harrison F, Lackersteen SM. Does personality affect risk for dementia? A systematic review and meta-analysis. Am. J. Geriatr. Psychiatry 2013; 21: 713-728.
    1. Wilson RS, Schneider JA, Arnold SE, Bienias JL, Bennett DA. Conscientiousness and the incidence of Alzheimer disease and mild cognitive impairment. Arch. Gen. Psychiatry 2007; 64: 1204-1212.
    1. Dong H, Goico B, Martin M, Csernansky CA, Bertchume A, Csernansky JG. Modulation of hippocampal cell proliferation, memory, and amyloid plaque deposition in APPsw (Tg2576) mutant mice by isolation stress. Neuroscience 2004; 127: 601-609.

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