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Percutaneous liver biopsy is a procedure in which a needle is introduced through the skin and into the liver tissue to obtain a specimen, aiding in the diagnosis, staging, and/or development of treatment modalities for various liver disorders. The first report of the procedure was in 1923. Given the advancements in imaging modalities such as ultrasound, computed tomography (CT), and magnetic resonance imaging (MRI) since that time, percutaneous liver biopsy can be further targeted towards specific lesions to improve biopsy accuracy and decrease the rate of overall complications. A liver biopsy is also an option, performed through a transvenous or laparoscopic route depending on the clinical context; however, the percutaneous route is generally the preferred approach. It is less invasive and less costly compared to other methods.
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