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Book

Prostaglandins

Kashif Malik  1 , Samar Nicolas  2 , Anterpreet Dua  3
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
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Affiliations
Book

Prostaglandins

Kashif Malik et al.

Excerpt

Prostaglandin analogs are synthetic compounds that mimic the effects of naturally occurring prostaglandins and are used for a wide range of clinical indications. They are used across multiple specialties, including ophthalmology, obstetrics, urology, gastroenterology, cardiology, and pulmonology. FDA-approved indications include PGF2α analogs (latanoprost, bimatoprost, travoprost, tafluprost, and latanoprostene bunod) for glaucoma; bimatoprost for eyelash hypotrichosis; PGE1 analogs (misoprostol and alprostadil) for NSAID-induced gastric ulcers, erectile dysfunction, and patent ductus arteriosus; PGF2α analog carboprost for postpartum hemorrhage and abortion induction; PGE2 analog dinoprostone for labor induction; and PGI2 analogs (epoprostenol, treprostinil, and iloprost) for pulmonary arterial hypertension, with iloprost also approved for severe frostbite. Misoprostol is also used off-label for labor induction, cervical ripening, pregnancy termination, and postpartum hemorrhage.

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Conflict of interest statement

Disclosure: Kashif Malik declares no relevant financial relationships with ineligible companies.

Disclosure: Samar Nicolas declares no relevant financial relationships with ineligible companies.

Disclosure: Anterpreet Dua declares no relevant financial relationships with ineligible companies.

References

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    1. Woodson SA. Latisse: empirical discovery yields treatment for sparse eyelashes. Nurs Womens Health. 2009 Jun;13(3):243-8. - PubMed
    1. Tang OS, Gemzell-Danielsson K, Ho PC. Misoprostol: pharmacokinetic profiles, effects on the uterus and side-effects. Int J Gynaecol Obstet. 2007 Dec;99 Suppl 2:S160-7. - PubMed

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