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Editorial
. 2020 Jan 27;12(2):1039-1041.
doi: 10.18632/aging.102806. Epub 2020 Jan 27.

In the heart of cardiac stromal senescence

Victorine Douin-Echinard  1   2 , Lise Lefevre  1   2 , Angelo Parini  1   2   3
Affiliations
Editorial

In the heart of cardiac stromal senescence

Victorine Douin-Echinard et al. Aging (Albany NY). .
No abstract available

Keywords: IL-1ß; heart; inflammaging; mesenchymal stromal cells; senescence.

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Figures

Figure 1
Figure 1
Cross-talk evolution between cardiomyocytes and cardiac stromal cell subsets during aging. During aging, cardiomyocytes and cardiac mesenchymal stromal cells (cMSC) acquire specific senescence associated secretory phenotypes (SASP) which promote age-related changes in the heart. Pro-angiogenic factors expressed by aged cMSCs increased frequencies of non-classical CD31+ cMSCs expressing endothelial related genes. SASP related pro-inflammatory mediators from cMSCs promote recruitment of monocyte-derived CCR2+ macrophages, with IL-1ß production re-enforcing cMSC senescence, cardiomyocyte hypertrophy and altered contractility. Concomitant acquisition of a non-conventional SASP by aged cardiomyocytes stimulates cardiomyocyte hypertrophy and myofibroblast activation.
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