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Editorial
. 2020 Feb;20(2):81-83.
doi: 10.1080/14737140.2020.1720654. Epub 2020 Jan 27.

Early detection and imaging strategies to reveal and target developing pancreatic cancer

Howard C Crawford  1 , Michael B Wallace  2 , Peter Storz  3
Affiliations
Editorial

Early detection and imaging strategies to reveal and target developing pancreatic cancer

Howard C Crawford et al. Expert Rev Anticancer Ther. 2020 Feb.
No abstract available

Keywords: PanIN; Pancreatic ductal adenocarcinoma; early detection; imaging; pancreatic intraepithelial neoplasia.

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Figures

Figure 1:
Figure 1:. Early Detection of Pancreatic Ductal Adenocarcinoma.
While PanIN2 still represent low-grade dysplasia, detection of PanIN3-associated changes is paramount to current efforts in early detection and imaging. In order to discover PDA at an early stage and to make it a preventable disease novel detection methods need to be established. These include the identification of circulating biomarkers in liquid biopsy (i.e. blood, pancreatic juice) or stool, as well as molecular imaging of lesion biomarkers (detection in situ) and possible molecular targeting of PDA based on these markers.
See this image and copyright information in PMC

References

    1. Cohen JD, Javed AA, Thoburn C et al. Combined circulating tumor DNA and protein biomarker-based liquid biopsy for the earlier detection of pancreatic cancers. Proc Natl Acad Sci U S A, 114(38), 10202–10207 (2017).

      * Provides a rationale for combination of circulating proteins and mutations in cell-free DNA for early detection of pancreatic cancer.

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