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Clinical Trial
. 1977 Feb 12;1(6058):413-4.
doi: 10.1136/bmj.1.6058.413.

Metabolic effects of salbutamol: comparison of aerosol and intravenous administration

A Neville, J B Palmer, J Gaddie, C S May, K N Palmer, L E Murchison
Clinical Trial

Metabolic effects of salbutamol: comparison of aerosol and intravenous administration

A Neville et al. Br Med J. .

Abstract

The effects of intravenous salbutamol (4 mug/kg) were compared with those of aerosol salbutamol (200 mug) in 10 asthmatic patients in a double-blind placebo-controlled study. Both methods of administration produced equal bronchodilatation. Intravenous salbutamol caused significant increases in plasma insulin and glucose levels and a fall in serum potassium concentration in addition to tachycardia and tremor, whereas aerosol salbutamol produced only a small transient increase in the plasma glucose level. The initially raised non-esterified fatty acid levels decreased significantly after aerosol and placebo but not after intravenous salbutamol.

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