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. 1977 Feb 12;1(6058):420-2.
doi: 10.1136/bmj.1.6058.420.

Successful bone marrow transplant for Fanconi's anaemia

A J Barrett, W D Brigden, J R Hobbs, K Hugh-Jones, J G Humble, D C James, S Retsas, T R Rogers, S Selwyn, P Sneath, J G Watson

Successful bone marrow transplant for Fanconi's anaemia

A J Barrett et al. Br Med J. .

Abstract

A 15-year-old boy with Fanconi's anaemia, who required four units of blood each month, received a bone marrow graft from his 9-year-old brother, who has HLA identical and compatible on mixed lymphocyte reaction. Considerable immunosuppression was used and bacterial infection was prevented by vigorous decontamination in a Vickers-Trexler isolator. After the graft the patient's blood counts remained satisfactory for nine months, but it took six months before qualitative immune function was normal.

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