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Comparative Study
. 2020 Jun;39(6):1109-1114.
doi: 10.1007/s10096-020-03822-x. Epub 2020 Jan 27.

Comparison of clinical outcomes of influenza A and B at the 2017-2018 influenza season: a cohort study

T Avni  1   2   3 , T Babich  2   3 , A Nir  3 , D Yahav  1   3 , H Shaked  1   3 , N Sorek  4 , H Ben Zvi  4 , J Bishara  1   3 , A Atamna  5   6
Affiliations
Comparative Study

Comparison of clinical outcomes of influenza A and B at the 2017-2018 influenza season: a cohort study

T Avni et al. Eur J Clin Microbiol Infect Dis. 2020 Jun.

Abstract

Influenza has significant morbidity and mortality. Some experts consider infection with influenza B as milder than that with influenza A. The objective of this study is to evaluate the outcomes of hospitalized patients with laboratory-confirmed influenza A or B in 2017-2018 influenza season. All hospitalized patients between October 2017 and April 2018 with laboratory-confirmed influenza A and B were included. The primary composite outcomes were pneumonia/myocarditis/encephalitis, mechanical ventilation, ICU admission, and 30-day mortality. Secondary outcomes were 30-/90-day mortality, length of hospital stay, and readmission rates. The study included 201 influenza A and 325 influenza B. For the primary composite outcome, no significant difference was demonstrated between influenza A and B. Rates of mortality were similar at 30 and 90 days. Influenza A had higher pneumonia rates and mechanical ventilation. On multivariate analysis, higher Charlson's score, hypoalbuminemia, and vasopressor use were associated with 30-day mortality, while infection with either influenza A or B was not. Influenza A was associated with higher pneumonia and mechanical ventilation rates. However, influenza B resulted with similar 30-day mortality rate as influenza A.

Keywords: H1N1; H3N2; Influenza; Mortality; Pneumonia.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

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