Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Feb;128(2):72-79.
doi: 10.1111/apm.13016. Epub 2020 Jan 28.

Human papillomavirus and urinary bladder cancer revisited

Kit Riegels Jørgensen  1   2 , Jørgen Bjerggaard Jensen  1   2
Affiliations
Review

Human papillomavirus and urinary bladder cancer revisited

Kit Riegels Jørgensen et al. APMIS. 2020 Feb.

Abstract

This review aims to present data on the association between human papillomavirus (HPV) and urinary bladder cancer (BC), especially of the subtype squamous cell carcinoma (SCC). Furthermore, the current data on the relation between p16, HPV, and BC are reviewed. PubMed was searched for 'Humans' [MESH] AND 'Papillomaviridae' [MESH] AND 'Urinary Bladder Neoplasms' [MESH], resulting in 157 potential articles. After profound reviewing, 18 articles were included in this review. Only original articles in English were included. A variable number of HPV genotypes in a small number of cases have been investigated in several studies with various methodology. HPV was present in 0-100% of cases depending on inclusion and exclusion criteria. SCC studies are mostly hampered by low number of cases whereas the few studies with a high number show a slightly higher prevalence of different HPV genotypes compared to pure urothelial carcinoma. Studies on p16 status in HPV positive cases are even more scarcely reported and show conflicting results. Most studies fail to prove clear-cut relevance of HPV in BC irrespectively of histological subtype. Negative p16 staining cannot rule out positive HPV status.

Keywords: Urinary bladder cancer; human papillomavirus; p16ink4a; squamous cell carcinoma.

PubMed Disclaimer

References

    1. Online database on international cancer statistics [Internet]. International Agency for Research on Cancer. Data source GLOBAN 2012. Available from: http://gco.iarc.fr/today/online-analysis-pie?v=2018&mode=cancer&... [Cited 2019 August 16].
    1. National clinical guidelines for treatment of bladder tumors in Denmark [Internet]. Denmark: Danish Bladder Cancer Group (DaBlaCa); 2012. Available from: http://skejby.net/Webudgaven/Pdf/DaBlaCa20maj202012.pdf [cited 2019 August 16].
    1. Huang W, Williamson SR, Rao Q, Lopez-Beltran A, Montironi R, Eble JN, et al. Novel markers of squamous differentiation in the urinary bladder. Hum Pathol 2013;44:1989-97.
    1. Kim SH, Joung JY, Chung J, Park WS, Lee KH, Seo HK. Detection of human papillomavirus infection and p16 immunohistochemistry expression in bladder cancer with squamous differentiation. PLoS ONE 2014;9:e93525.
    1. Westenend PJ, Stoop JA, Hendriks JG. Human papillomaviruses 6/11, 16/18 and 31/33/51 are not associated with squamous cell carcinoma of the urinary bladder. BJU Int 2001;88:198-201.

MeSH terms

Substances