Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Dec 1;168(6):2373-8.
doi: 10.1084/jem.168.6.2373.

Virally induced modulation of murine IgG antibody subclasses

J P Coutelier  1 , J T van der Logt, F W Heessen, A Vink, J van Snick
Affiliations

Virally induced modulation of murine IgG antibody subclasses

J P Coutelier et al. J Exp Med. .

Abstract

The isotypic distribution of murine IgG was examined after infection with several viruses. The results indicate that when a hypergammaglobulinemia was induced by the infection, it was restricted to the IgG2a and, to a lesser extent, to the IgG2b subclasses. In addition, when mice were infected with some viruses concomitantly with the immunization with a soluble protein antigen, a modification in the isotypic distribution of antiprotein antibodies was observed, with a preferential production of IgG2a. These observations indicate that viral infections can actively influence the switch of Igs and selectively stimulate the production of the IgG2a subclass.

PubMed Disclaimer

References

    1. Arch Gesamte Virusforsch. 1972;38(2):167-76 - PubMed
    1. Nature. 1988 Jul 21;334(6179):255-8 - PubMed
    1. J Immunol. 1978 Aug;121(2):566-72 - PubMed
    1. J Exp Med. 1979 Sep 19;150(3):517-30 - PubMed
    1. Immunology. 1979 Dec;38(4):687-95 - PubMed

Publication types