Laser interstitial thermal therapy in gliomas

Oliver Bozinov¹, Yang Yang², Markus F Oertel², Marian C Neidert³, Peter Nakaji⁴

Affiliations

¹ Department of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Frauenklinikstrasse 10, 8002, Zurich, Switzerland. Electronic address: Oliver.Bozinov@usz.ch.
² Department of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Frauenklinikstrasse 10, 8002, Zurich, Switzerland.
³ Department of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Frauenklinikstrasse 10, 8002, Zurich, Switzerland; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA; Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA.
⁴ Department of Neurosurgery, University of Arizona College of Medicine Phoenix, Banner Health, 755 East McDowell Road, Phoenix, AZ, 85006, USA.

PMID: 31991153
DOI: 10.1016/j.canlet.2020.01.024

Review

Laser interstitial thermal therapy in gliomas

Oliver Bozinov et al. Cancer Lett. 2020.

. 2020 Apr 1:474:151-157.

doi: 10.1016/j.canlet.2020.01.024. Epub 2020 Jan 25.

Authors

Oliver Bozinov¹, Yang Yang², Markus F Oertel², Marian C Neidert³, Peter Nakaji⁴

Affiliations

¹ Department of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Frauenklinikstrasse 10, 8002, Zurich, Switzerland. Electronic address: Oliver.Bozinov@usz.ch.
² Department of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Frauenklinikstrasse 10, 8002, Zurich, Switzerland.
³ Department of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Frauenklinikstrasse 10, 8002, Zurich, Switzerland; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA; Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA.
⁴ Department of Neurosurgery, University of Arizona College of Medicine Phoenix, Banner Health, 755 East McDowell Road, Phoenix, AZ, 85006, USA.

PMID: 31991153
DOI: 10.1016/j.canlet.2020.01.024

Abstract

Laser interstitial thermal therapy (LITT) has been used for brain metastasis, epilepsy, and necrosis, as well as gliomas as a minimally invasive treatment for many years. With the improvement of the thermal monitoring and ablation precision, especially the application of magnetic resonance (MR) thermography in the procedure and the available two commercial laser systems nowadays, LITT is gradually accepted by more neurosurgical centers. Recently, some new concepts, for example the adjuvant chemotherapy or radiation following LITT, the combination of immunotherapy and LITT regarding the glioma treatment are proposed and currently being investigated. The aim of this study is to summarize the evolution of LITT especially for brain gliomas and a possible outlook of the future.

Keywords: Blood brain barrier; Gliomas; Immunotherapy; Laser interstitial thermal therapy.

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Conflict of interest statement

Declaration of competing interest The authors declare no conflict of interest.

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Laser interstitial thermal therapy in gliomas

Affiliations

Laser interstitial thermal therapy in gliomas

Authors

Affiliations

Abstract

Conflict of interest statement

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Medical