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. 1977 Jan;16(1):39-55.
doi: 10.1016/0009-2797(77)90152-1.

The interaction of an anti-tumour platinum complex with DNA

I A Roos

The interaction of an anti-tumour platinum complex with DNA

I A Roos. Chem Biol Interact. 1977 Jan.

Abstract

The interaction of the anti-tumour active cis platinum (II) complexes with DNA has been investigated using dichloro(ethylenediamine)platinum(II) and E. coli DNA. Equilibrium dialysis studies indicate that Pt(en)Cl2 binds reversibly to DNA to a saturation value of 0.57 Pt: P, which is consistent with the platinum being bound both monofunctionally and bifunctionally. Pt(en)Cl2 inhibits the intercalation of 9-aminoacridine (9AA) by cross-linking the bases of the double helix, but at no stage does all the bound platinum cross-link. It is suggested that this inhibition of intercalation is due to intrastrand cross-linking.

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