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. 2019 Dec;48(12):2177-2186.

Procalcitonin, C-Reactive Protein, and Neutrophil Ratio Contribute to the Diagnosis and Prognosis of Severe Acute Pancreatitis

Yi Liang  1 , Xianwei Zhao  2 , Fanliang Meng  1
Affiliations

Procalcitonin, C-Reactive Protein, and Neutrophil Ratio Contribute to the Diagnosis and Prognosis of Severe Acute Pancreatitis

Yi Liang et al. Iran J Public Health. 2019 Dec.

Abstract

Background: We aimed to explore the significance of procalcitonin (PCT), C-reactive protein (CRP) and neutrophil ratio (N%) in the early diagnosis, treatment, and prognosis of severe acute pancreatitis (SAP).

Methods: A total of 104 patients with SAP (SAP group) and 101 patients with mild acute pancreatitis (MAP) (MAP group) admitted to Affiliated Hospital of Jining Medical University, Jining, China were enrolled. The PCT and CRP in serum were detected by a full-automatic biochemical analyzer, and N% in peripheral blood was measured by a hemocyte analyzer.

Results: The peripheral blood PCT, CRP, and N% in the SAP group were significantly higher than those in the MAP group (P<0.001). Multivariate Logistic regression analysis showed that acute physiology and chronic health evaluation II (APACHE II) score, Ranson score, PCT, CRP, and N% were independent risk factors for SAP. The receiver operating characteristic (ROC) curve showed that the area under curve (AUC) of PCT, CRP, and N% in diagnosing SAP were 0.906, 0.840, and 0.834 respectively, while that of combined detection was 0.972. The AUC of PCT, CRP, and N% in diagnosing SAP death were 0.907, 0.900, and 0.894, respectively.

Conclusions: Peripheral blood PCT, CRP, and N% contribute to the diagnosis and prognosis of SAP.

Keywords: Acute severe pancreatitis; C-reactive protein; Diagnosis; Neutrophil ratio; Procalcitonin.

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Conflict of interest statement

Conflicts of interests The authors declare that there is no conflict of interests.

Figures

Fig. 1:
Fig. 1:
ROC curves of peripheral blood PCT (A), CRP (B), N% (C), and their combination (D) in diagnosing SAP
Fig. 2:
Fig. 2:
Correlations of PCT, CRP, and N% with APACHE-II score and Ranson score in SAP. PCT (A), CRP (B), and N% (C) were positively correlated with APACHE-II scor. PCT (D), CRP(E), and N% (F) were positively correlated with Ranson score
Fig. 3:
Fig. 3:
Changes of peripheral blood PCT (A), CRP (B) and N% (C) at different time points after admission
Fig. 4:
Fig. 4:
ROC curves of peripheral blood PCT (A), CRP (B), and N% (C) in diagnosing SAP death
See this image and copyright information in PMC

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