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. 2020 Mar;277(3):833-840.
doi: 10.1007/s00405-020-05789-z. Epub 2020 Jan 29.

Lymph node density as a predictive factor for worse outcomes in laryngeal cancer

Sílvia Petrarolha  1 , Rogério Dedivitis  2 , Leandro Matos  2 , Daniel Ramos  2 , Marco Kulcsar  3
Affiliations

Lymph node density as a predictive factor for worse outcomes in laryngeal cancer

Sílvia Petrarolha et al. Eur Arch Otorhinolaryngol. 2020 Mar.

Abstract

Background: The lymph node density (LND) is the number of positive metastatic lymph nodes divided by the total number of dissected lymph nodes. The purpose of this study was to evaluate LND as a prognostic factor in patients with laryngeal squamous cell carcinoma (SCC).

Methods: The study included 186 patients with laryngeal SCC submitted to laryngeal surgical treatment with neck dissection between January 2009 and December 2016. Clinical-pathological variables were assessed, as well as the cut-off point for LND.

Results: LND value was calculated considering pN+ (LND = 0.060). The Kaplan-Meier curve (log-rank) related to cumulative survival demonstrated that patients with LND ≥ 0.060 had a higher mortality rate than those with LND < 0.060, presenting a more aggressive form of the disease, with earlier recurrence. However, only the LND ≥ 0.060 group had impact on both disease-free survival and overall survival.

Conclusion: The LND proved to be an important index in the prognostic evaluation of larynx SCC patients having a direct relationship with disease recurrence. Patients with LND ≥ 0.060 should be considered for adjuvant therapy.

Keywords: Dissection; Head and neck cancer; Laryngeal cancer; Lymph node density; Prognostic factors; Squamous cell carcinoma; neck.

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References

    1. Prabhu RS, Hanasoge S, Magliocca KR, Hall WA, Chen SA, Higgins KA, Saba NF, Deiry M, Grist W, Wadsworth JT, Chen AY, Beitler JJ (2015) Lymph node ratio influence on risk of head and neck cancer locoregional recurrence after initial surgical resection: implications for adjuvant therapy. Head Neck 37(6):777–782 - PubMed - DOI
    1. Bernier J, Domenge C, Ozsahin M, Matuszewska K, Lefèbvre JL, Greiner RH, Giralt J, Maingon P, Rolland F, Bolla M, Cognetti F, Bourhis J, Kirkpatrick A, van Glabbeke M, European Organization for Research and Treatment of Cancer Trial 22931 (2004) Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer. N Engl J Med 350(19):1945–1952 - PubMed - DOI
    1. Wang YL, Li DS, Wang Y, Wang ZY, Ji QH (2014) Lymph node ratio for postoperative staging of laryngeal squamous cell carcinoma with lymph node metastasis. PLoS ONE ONE 9(7):e87037 - DOI
    1. Ryu IS, Roh JL, Cho KJ, Choi SH, Nam SY, Kim SY (2015) Lymph node density as an independent predictor of cancer-specific mortality in patients with lymph node-positive laryngeal squamous cell carcinoma after laryngectomy. Head Neck 37(9):1319–1325 - PubMed - DOI
    1. Künzel J, Mantsopoulos K, Psychogios G, Agaimy A, Grundtner P, Koch M, Iro H (2015) Lymph node ratio is of limited value for the decision-making process in the treatment of patients with laryngeal cancer. Eur Arch Otorhinolaryngol 272(2):453–461 - PubMed - DOI

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