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Review
. 2020 Jan 30:26:e919159.
doi: 10.12659/MSM.919159.

Osteopontin in Bone Metabolism and Bone Diseases

Jinyan Si  1   2 , Chaowei Wang  1   2 , Denghui Zhang  1   2 , Bo Wang  3 , Yi Zhou  1   2
Affiliations
Review

Osteopontin in Bone Metabolism and Bone Diseases

Jinyan Si et al. Med Sci Monit. .

Abstract

Osteopontin (OPN), a secreted phosphoprotein, is a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family of cell matrix proteins and participates in many biological activities. Studies have shown that OPN plays a role in bone metabolism and homeostasis. OPN not only is an important factor in neuron-mediated and endocrine-regulated bone mass, but also is involved in biological activities such as proliferation, migration, and adhesion of several bone-related cells, including bone marrow mesenchymal stem cells, hematopoietic stem cells, osteoclasts, and osteoblasts. OPN has been demonstrated to be closely related to the occurrence and development of many bone-related diseases, such as osteoporosis, rheumatoid arthritis, and osteosarcoma. As expected, the functions of OPN in the bone have become a research hotspot. In this article, we try to decipher the mechanism of OPN-regulated bone metabolism and bone diseases.

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Conflict of interest statement

Conflict of interest.

None.

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