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. 2020 Mar;35(3):473-482.
doi: 10.1007/s11011-020-00537-y. Epub 2020 Jan 29.

Protective effect of D-pinitol on the experimental spinal cord injury in rats

Yan An  1 , Jianing Li  1 , Yajun Liu  1 , Mingxing Fan  1 , Wei Tian  2
Affiliations

Protective effect of D-pinitol on the experimental spinal cord injury in rats

Yan An et al. Metab Brain Dis. 2020 Mar.

Abstract

Spinal cord injury (SCI) is the major cause of the spinal damage affecting motor and sensory function. Thus, the present study was conducted to investigate the effect of D-pinitol (PN) on spinal cord injury in rats. The PN showed to recover motor function near to normal via modulating oxidative stress, inflammatory response and cellular apoptosis in SCI rats. PN also causes modulation of Bcl2 family proteins and reduces the level of NF-ĸB and LOX-1 in dose dependent manner. The PN causes reduction of NLRP3, TNF-α and iNOS, with increase in caspase-1 together with modulation of MAPK mediators. It has been suggested that, D-pinitol exert protective action against SCI via inhibition of apoptosis, inflammation and oxidative stress, via modulating Bcl-2 genes and MAPK pathway.

Keywords: Apoptosis; D-pinitol; Inflammation; Oxidative stress.

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