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. 2019 Dec;36(6):692-702.
doi: 10.5114/ada.2019.91420. Epub 2019 Dec 30.

Evaluation of serum lipid, lipoprotein, and apolipoprotein levels in psoriatic patients: a systematic review and meta-analysis of case-control studies

Mazaher Ramezani  1 , Elisa Zavattaro  2 , Masoud Sadeghi  3   4
Affiliations

Evaluation of serum lipid, lipoprotein, and apolipoprotein levels in psoriatic patients: a systematic review and meta-analysis of case-control studies

Mazaher Ramezani et al. Postepy Dermatol Alergol. 2019 Dec.

Abstract

Introduction: Psoriasis is a T cell-mediated inflammatory skin disease in which fatty acids may be a link between psoriasis and its comorbidity.

Aim: The present meta-analysis aimed to evaluate lipid, lipoprotein, and apolipoprotein levels in the psoriatic patients compared with the control subjects.

Material and methods: Four databases, including Web of Science, Scopus, PubMed, and Cochrane Library were searched until July 2017. All records analysed were case-control studies. The quality of the questionnaires was evaluated using the Newcastle-Ottawa Scale (NOS). A random-effects meta-analysis was done by Rev Man 5.3 using mean difference (MD) and 95% confidence intervals (CIs).

Results: Out of 580 studies identified in four databases, 49 studies were included and analysed in this meta-analysis. The results showed that MD of total cholesterol, triglyceride, LDL, VLDL, HDL, Lp(a), Apo A1, and Apo B levels in the patients compared with the controls were (MD = 13.74 mg/dl; 95% CI: 7.72-19.75; p< 0.00001), (MD = 26.04 mg/dl; 95% CI: 20.77-31.31; p< 0.00001), (MD = 11.41 mg/dl; 95% CI: 6.26-16.57; p< 0.0001), (MD = 4.82 mg/dl; 95% CI: 3.63-6.00; p< 0.00001), (MD = -2.78 mg/dl; 95% CI: -4.53 - -1.03; p< 0.002), (MD = 8.51 mg/dl; 95% CI: 4.86-12.17; p< 0.0001), (MD = -6.60 mg/dl; 95% CI: -13.96 - 0.75; p< 0.08), and (MD = 9.70 mg/dl; 95% CI: 3.02-16.39; p< 0.004), respectively.

Conclusions: This meta-analysis identified abnormality of serum lipid, lipoprotein, and apolipoproteinprofiles in psoriatic patients compared with the controls as well as possibly a greater risk of atherosclerosis and cardiovascular (CV) accidents in the patients.

Keywords: apolipoprotein; lipid; lipoprotein; psoriasis; serum.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flow-chart of the stud
Figure 2
Figure 2
Forest plot of random-effects model of serum total cholesterol levels in psoriatic patients compared with healthy controls
Figure 3
Figure 3
Forest plot of random-effects model of serum triglyceride (TG) levels in psoriatic patients compared with healthy controls
Figure 4
Figure 4
Forest plot of random-effects model of serum low-density lipoprotein (LDL) levels in psoriatic patients compared with healthy controls
Figure 5
Figure 5
Forest plot of random-effects model of serum very low-density lipoprotein (VLDL) levels in psoriatic patients compared with healthy controls
Figure 6
Figure 6
Forest plot of random-effects model of serum high-density lipoprotein (HDL) levels in psoriatic patients compared with healthy controls
Figure 7
Figure 7
Forest plot of random-effects model of serum lipoprotein (a) or Lp(a) (A), Apolipoprotein A1 (B), and Apolipoprotein B (C) levels in psoriatic patients compared with healthy controls
See this image and copyright information in PMC

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