doi: 10.1016/0022-4731(88)90008-8.
Purification, monoclonal antibody production and structural analyses of human progesterone receptors
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- PMID: 3199807
- DOI: 10.1016/0022-4731(88)90008-8
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Purification, monoclonal antibody production and structural analyses of human progesterone receptors
J Steroid Biochem.
1988 Oct.
Abstract
Progesterone receptors (PR) from human breast cancer cells have been purified, and used as antigens to generate anti-PR monoclonal antibodies. Immunologic and in situ photoaffinity labeling methods were then used to study receptor structure, and we conclude that native human PR consist of two independent 8S receptors: one 8S subtype contains B-proteins (120,000 kDa) and the other contains A-proteins (94,000 kDa).
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