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. 1988 Oct;31(4B):573-8.
doi: 10.1016/0022-4731(88)90008-8.

Purification, monoclonal antibody production and structural analyses of human progesterone receptors

K B Horwitz  1
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Purification, monoclonal antibody production and structural analyses of human progesterone receptors

K B Horwitz. J Steroid Biochem. 1988 Oct.

Abstract

Progesterone receptors (PR) from human breast cancer cells have been purified, and used as antigens to generate anti-PR monoclonal antibodies. Immunologic and in situ photoaffinity labeling methods were then used to study receptor structure, and we conclude that native human PR consist of two independent 8S receptors: one 8S subtype contains B-proteins (120,000 kDa) and the other contains A-proteins (94,000 kDa).

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