Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Jan 10:10:1365.
doi: 10.3389/fneur.2019.01365. eCollection 2019.

Pentraxin 3, TNF-α, and LDL-C Are Associated With Carotid Artery Stenosis in Patients With Ischemic Stroke

Li Yi  1 , Jie Tang  2 , Cuige Shi  3 , Tingting Zhang  4 , Jing Li  4 , Fang Guo  1 , Wei Zhang  1
Affiliations

Pentraxin 3, TNF-α, and LDL-C Are Associated With Carotid Artery Stenosis in Patients With Ischemic Stroke

Li Yi et al. Front Neurol. .

Abstract

Background: Carotid artery stenosis (CAS), typically resulting from atherosclerotic progression, is more common than intracranial atherosclerotic disease in patients with cerebrovascular disease. Prior literature has incompletely established the relationship of Pentraxin 3 (PTX3) and CAS complexity and severity. This study aims to more thoroughly evaluate the association of plasma PTX3 levels and the prevalence and severity of CAS in patients with cerebrovascular disease. Methods: Two hundred and six patients with ischemic stroke underwent multiphase computerized tomography angiography (CTA) of the head and neck to assess the presence and severity of carotid artery stenosis. Patients were divided into groups with either no carotid artery stenosis (CAS-free) or carotid artery stenosis (CAS). The CAS group was further divided into groups based on the degree of stenosis and the number of involved vessels. The PTX3 and Tumor Necrosis Factor-alpha (TNF-α) concentration were measured by ELISA. Results: Plasma levels of PTX3, TNF-α, and low-density lipoprotein cholesterol (LDL-C) were increased significantly in the CAS group patients vs. the CAS-free group (p = 0.000, 0.002, 0.002, respectively). Within the CAS group, PTX3, TNF-α, and LDL-C were significantly elevated in stenosis of ≥50% group compared to <50% group (p = 0.001, 0.002, 0.049, respectively). The multivariate logistic binary regression analysis revealed that increased age, elevated levels of PTX3, LDL-C, and TNF-α were all independent risk factors for occurrence of carotid stenosis. PTX3 level correlated with the severity of carotid stenosis. Conclusions: High plasma PTX3 levels, TNF-α, and LDL-C are significantly correlated with the prevalence and severity of carotid artery stenosis. PTX3 may be a more powerful predictor for the severity of carotid artery stenosis.

Keywords: LDL-cholesterol; Pentraxin 3 (PTX3); TNF-α; carotid artery stenosis (CAS); ischemic stroke.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Comparison of plasma PTX3 levels between the control group and each stenosis subgroup.
See this image and copyright information in PMC

References

    1. Uchino K, Risser JM, Smith MA, Moyé LA, Morgenstern LB. Ischemic stroke subtypes among Mexican Americans and non-Hispanic whites: the BASIC project. Neurology. (2004) 63:574–6. 10.1212/01.WNL.0000133212.99040.07 - DOI - PubMed
    1. Saba L, Mallarini G. A comparison between NASCET and ECST methods in the study of carotids: evaluation using Multi-Detector-Row CT angiography. Eur J Radiol. (2010) 76:42–7. 10.1016/j.ejrad.2009.04.064 - DOI - PubMed
    1. Lovrencic-Huzjan A, Rundek T, Katsnelson M. Recommendations for management of patients with carotid stenosis. Stroke Res Treat. (2012) 2012:175869. 10.1155/2012/175869 - DOI - PMC - PubMed
    1. Flaherty ML, Kissela B, Khoury JC, Alwell K, Moomaw CJ, Woo D, et al. Carotid artery stenosis as a cause of stroke. Neuroepidemiology. (2013) 40:36–41. 10.1159/000341410 - DOI - PMC - PubMed
    1. Shindo A, Maki T, Mandeville ET, Liang AC, Egawa N, Itoh K, et al. Astrocyte-derived Pentraxin 3 supports blood-brain barrier integrity under acute phase of stroke. Stroke. (2016) 47:1094–100. 10.1161/STROKEAHA.115.012133 - DOI - PMC - PubMed