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Review
. 2020 Jan 9:10:1291.
doi: 10.3389/fgene.2019.01291. eCollection 2019.

H3K36 Methylation in Neural Development and Associated Diseases

Mattia Zaghi  1 , Vania Broccoli  1   2 , Alessandro Sessa  1
Affiliations
Review

H3K36 Methylation in Neural Development and Associated Diseases

Mattia Zaghi et al. Front Genet. .

Abstract

Post-translational methylation of H3 lysine 36 (H3K36) is an important epigenetic marker that majorly contributes to the functionality of the chromatin. This mark is interpreted by the cell in several crucial biological processes including gene transcription and DNA methylation. The homeostasis of H3K36 methylation is finely regulated by different enzyme classes which, when impaired, lead to a plethora of diseases; ranging from multi-organ syndromes to cancer, to pure neurological diseases often associated with brain development. This mini-review summarizes current knowledge on these important epigenetic signals with emphasis on the molecular mechanisms that (i) regulate their abundance, (ii) are influenced by H3K36 methylation, and (iii) the associated diseases.

Keywords: DNA metyltransferases (Dnmts); H3K36; SET – Su(var)3–9 and ‘Enhancer of zeste’; histone methyl transferase (HMT); neurodevelopment.

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Figures

Figure 1
Figure 1
Homeostasis of H3K36 methylation. Depiction of the transition between the different states or chromatin marks of lysine 36 of histone H3. Known enzymes found in mammals able to add or removemethyl groups are highlighted. Created with BioRender.com.
Figure 2
Figure 2
Association between H3K36 methylation and biological processes. Depiction of the linkage between H3K36 HMTs with either DNA methylation distribution or transcription including co-transcriptional processes (RNA splicing is shown). Associated diseases are also highlighted. Created with BioRender.com.
See this image and copyright information in PMC

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