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Review
. 2020 Jan 3:2020:3028387.
doi: 10.1155/2020/3028387. eCollection 2020.

The Multifarious Link between Cytochrome P450s and Cancer

Abdullah M Alzahrani  1 , Peramaiyan Rajendran  1
Affiliations
Review

The Multifarious Link between Cytochrome P450s and Cancer

Abdullah M Alzahrani et al. Oxid Med Cell Longev. .

Abstract

Cancer is a leading cause of death worldwide. Cytochrome P450s (P450s) play an important role in the metabolism of endogenous as well as exogenous substances, especially drugs. Moreover, many P450s can serve as targets for disease therapy. Increasing reports of epidemiological, diagnostic, and clinical research indicate that P450s are enzymes that play a major part in the formation of cancer, prevention, and metastasis. The purposes of this review are to shed light on the current state of knowledge about the cancer molecular mechanism involving P450s and to summarize the link between the cancer effects and the participation of P450s.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
The potential role of P450 family proteins in cancer.
Figure 2
Figure 2
P450s in cancer formation.
Figure 3
Figure 3
P450s in metastasis and the EET pathways. Blue depicts the crosstalk between the tumor epithelium, endothelial cells, and lymphocytes. This figure was adapted from Edson and Rettie [89].
Figure 4
Figure 4
P450s in chemoprevention.
See this image and copyright information in PMC

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