Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2019 Dec 17;8(1):108-115.
doi: 10.1002/ccr3.2558. eCollection 2020 Jan.

Hepatic epithelioid hemangioendothelioma successfully treated with living donor liver transplantation: A case report and literature review

Sotaro Fukuhara  1 , Hiroyuki Tahara  1 , Yoshito Hirata  1 , Kosuke Ono  1 , Michinori Hamaoka  1 , Seiichi Shimizu  1 , Shinji Hashimoto  1 , Shintaro Kuroda  1 , Masahiro Ohira  1 , Kentaro Ide  1 , Tsuyoshi Kobayashi  1 , Hideki Ohdan  1
Affiliations
Case Reports

Hepatic epithelioid hemangioendothelioma successfully treated with living donor liver transplantation: A case report and literature review

Sotaro Fukuhara et al. Clin Case Rep. .

Abstract

Hepatic epithelioid hemangioendothelioma is a rare neoplasm with a variable malignant potential and a high risk of recurrence. No general treatment guidelines have been established. Fortunately, we were able to minimize immunosuppressant after liver transplantation because of a full HLA-matched case. There was no recurrence 1 year after treatment.

Keywords: hepatic epithelioid hemangioendothelioma; liver transplantation; mTOR inhibitor.

PubMed Disclaimer

Conflict of interest statement

None of the authors has any conflicts of interest to disclose.

Figures

Figure 1
Figure 1
A, Plain computed tomography (CT) revealed multiple tumors with low‐density areas in both hepatic lobes. B‐D, Contrast‐enhanced CT showed the tumor with a slight circular enhancement in the early phase. The enhancement was prolonged to the delayed phase, up to 40 × 46 mm in size
Figure 2
Figure 2
A and B, Magnetic resonance imaging (MRI) showed the tumor with a hypointensity on the T1‐weighted images and a hyperintensity on the T2‐weighted images. C and D, The dynamic MRI study showed the tumor with a heterogeneous enhancement in the early phase and a defect of enhancement in the Kupffer phase
Figure 3
Figure 3
A and B, Fluorin‐18 fluorodeoxyglucose positron emission tomography CT revealed that the tumors had a high accumulation, with a maximum standardized uptake value of 4.9, unlike the other organs
Figure 4
Figure 4
A and B, The histopathological findings revealed that the epithelioid cells were infiltrating the hepatic sinusoids invasively or substitutability. The tumor cells also infiltrated the portal vein and hepatic vein
Figure 5
Figure 5
A and B, Contrast‐enhanced CT conducted 12 mo after liver transplantation showed no finding of recurrence or metastasis in the liver graft or the other organs
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Weiss SW, Enzinger FM. Epithelioid hemangioendothelioma: a vascular tumor often mistaken for a carcinoma. Cancer. 1982;50:970‐981. - PubMed
    1. Mehrabi A, Kashfi A, Fonouni H, et al. Primary malignant hepatic epithelioid hemangioendothelioma: a comprehensive review of the literature with emphasis on the surgical therapy. Cancer. 2006;107:2108‐2121. - PubMed
    1. Lerut JP, Orlando G, Adam R, et al. for European Liver Transplant Registry. The place of liver transplantation in the treatment of hepatic epitheloid hemangioendothelioma: report of the European Liver Transplant Registry. Ann Surg. 2007;246:949‐957. - PubMed
    1. Sieghart W, Fuereder T, Schmid K, et al. Mammalian target of rapamycin pathway activity in hepatocellular carcinomas of patients undergoing liver transplantation. Transplantation. 2007;83:425‐432. - PubMed
    1. Sahin F, Kannangai R, Adegbola O, Wang J, Su G, Torbenson M. mTOR and P70 S6 kinase expression in primary liver neoplasms. Clin Cancer Res. 2004;10:8421‐8425. - PubMed

Publication types