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Case Reports
. 2019 Dec 17;8(1):108-115.
doi: 10.1002/ccr3.2558. eCollection 2020 Jan.

Hepatic epithelioid hemangioendothelioma successfully treated with living donor liver transplantation: A case report and literature review

Sotaro Fukuhara  1 , Hiroyuki Tahara  1 , Yoshito Hirata  1 , Kosuke Ono  1 , Michinori Hamaoka  1 , Seiichi Shimizu  1 , Shinji Hashimoto  1 , Shintaro Kuroda  1 , Masahiro Ohira  1 , Kentaro Ide  1 , Tsuyoshi Kobayashi  1 , Hideki Ohdan  1
Affiliations
Case Reports

Hepatic epithelioid hemangioendothelioma successfully treated with living donor liver transplantation: A case report and literature review

Sotaro Fukuhara et al. Clin Case Rep. .

Abstract

Hepatic epithelioid hemangioendothelioma is a rare neoplasm with a variable malignant potential and a high risk of recurrence. No general treatment guidelines have been established. Fortunately, we were able to minimize immunosuppressant after liver transplantation because of a full HLA-matched case. There was no recurrence 1 year after treatment.

Keywords: hepatic epithelioid hemangioendothelioma; liver transplantation; mTOR inhibitor.

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Conflict of interest statement

None of the authors has any conflicts of interest to disclose.

Figures

Figure 1
Figure 1
A, Plain computed tomography (CT) revealed multiple tumors with low‐density areas in both hepatic lobes. B‐D, Contrast‐enhanced CT showed the tumor with a slight circular enhancement in the early phase. The enhancement was prolonged to the delayed phase, up to 40 × 46 mm in size
Figure 2
Figure 2
A and B, Magnetic resonance imaging (MRI) showed the tumor with a hypointensity on the T1‐weighted images and a hyperintensity on the T2‐weighted images. C and D, The dynamic MRI study showed the tumor with a heterogeneous enhancement in the early phase and a defect of enhancement in the Kupffer phase
Figure 3
Figure 3
A and B, Fluorin‐18 fluorodeoxyglucose positron emission tomography CT revealed that the tumors had a high accumulation, with a maximum standardized uptake value of 4.9, unlike the other organs
Figure 4
Figure 4
A and B, The histopathological findings revealed that the epithelioid cells were infiltrating the hepatic sinusoids invasively or substitutability. The tumor cells also infiltrated the portal vein and hepatic vein
Figure 5
Figure 5
A and B, Contrast‐enhanced CT conducted 12 mo after liver transplantation showed no finding of recurrence or metastasis in the liver graft or the other organs
See this image and copyright information in PMC

References

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