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Case Reports
. 2019 Dec 19;8(1):190-193.
doi: 10.1002/ccr3.2601. eCollection 2020 Jan.

Coronary vasospasm induced by cisplatin for seminoma

Wataru Sasaki  1 , Hiroshi Wada  1 , Kenichi Sakakura  1 , Jun Matsuda  1 , Tatsuro Ibe  1 , Takekuni Hayashi  1 , Hirohito Ueba  1 , Shin-Ichi Momomura  1 , Hideo Fujita  1
Affiliations
Case Reports

Coronary vasospasm induced by cisplatin for seminoma

Wataru Sasaki et al. Clin Case Rep. .

Abstract

Vascular toxicity is one of serious complications following cisplatin-based chemotherapy. This case suggests that cisplatin has a potential risk of delayed occurrence of vasospastic angina. It is important to perform careful history taking including discontinued drugs for differential diagnosis of chest pain.

Keywords: acetylcholine provocation test; chemotherapy; cisplatin; coronary vasospastic angina; onco‐cardiology.

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Conflict of interest statement

The authors declare that there is no conflict of interest.

Figures

Figure 1
Figure 1
Electrocardiography on admission. There was no abnormal ST elevation in electrocardiography at rest
Figure 2
Figure 2
Coronary angiography and acetylcholine provocation test. (A) (upper column, left) Coronary angiography before acetylcholine infusion. There was not any organic stenosis in coronary artery, (B) (upper column, middle) after 50 µg of acetylcholine injection. (Catheter was not wedged position because left anterior descending artery was total occluded by severe coronary spasm.) (C) (upper column, right) After nitroglycerin. Dilatation of coronary artery by nitroglycerin was observed. (D) (lower column, left) electrocardiography and atrial pressure waveform before acetylcholine injection. There was no remarkable ST elevation. (E) (lower column, right) electrocardiography and atrial pressure waveform just after acetylcholine infusion, at same time as C. Remarkable ST elevation with severe chest pain was shown in II, III, aVF, and V1‐V6 leads. Atrial pressure (red arrow) decreased gradually under 80 mm Hg
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