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. 2020 Jan 10:7:370.
doi: 10.3389/fcell.2019.00370. eCollection 2019.

Understanding the Spatial Topology of Artificial Immunological Synapses Assembled in T Cell-Redirecting Strategies: A Major Issue in Cancer Immunotherapy

Pedro Roda-Navarro  1   2 , Luis Álvarez-Vallina  3   4
Affiliations

Understanding the Spatial Topology of Artificial Immunological Synapses Assembled in T Cell-Redirecting Strategies: A Major Issue in Cancer Immunotherapy

Pedro Roda-Navarro et al. Front Cell Dev Biol. .
No abstract available

Keywords: CAR T cell; bispecific antibodies; cancer; immunological synapse; immunotherapy.

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Figures

Figure 1
Figure 1
Factors potentially affecting IS topology. (A) Reported topology observed in the TCR-mediated, CAR-mediated and bsAb-mediated IS. The organization of cytoskeleton, signaling and effector molecules along the interface of the IS established by T cells and target cells is depicted. The TCR-mediated and the bsAb-mediated IS display a well-organized bull's eye structure whereas CAR-mediated IS shows a rather disordered structure. Bidirectional arrow and question mark indicate the uncertainty of expected topology in future CAR and bsAb formats. (B) Schematic of the activating system in TCR-mediated physiological IS or CCB-mediated artificial IS. The different factors influencing IS assembly and T cell activation are indicated in the tumor cell and in the T cell.
See this image and copyright information in PMC

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