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Comment
. 2020 Jan 31;367(6477):510-511.
doi: 10.1126/science.aba4472.

Monitoring neuronal health

Axel Nimmerjahn  1
Affiliations
Comment

Monitoring neuronal health

Axel Nimmerjahn. Science. .
No abstract available

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Figures

None
A microglial process (green) with P2Y purinoceptor 12 (black) contacts a neuron cell body (pink) in mouse.
None
Microglia protect neurons
During homeostasis, low amounts of ATP released from active neurons are converted to ADP and detected by microglial processes through P2Y12 receptors, leading to increased contact time with cell bodies and NADH in neurons. After neuronal injury, high concentrations of extracellular ATP increase coverage by microglial processes that protect viable neurons from cell death, although the precise mechanisms remain unknown. ADP, adenosine diphosphate; ATP, adenosine triphosphate; Kv2.1, voltage-gated potassium channel 2.1; NADH, nicotinamide adenine dinucleotide; P2Y12 receptor, P2Y purinoceptor 12.
See this image and copyright information in PMC

Comment on

  • Microglia monitor and protect neuronal function through specialized somatic purinergic junctions.
    Cserép C, Pósfai B, Lénárt N, Fekete R, László ZI, Lele Z, Orsolits B, Molnár G, Heindl S, Schwarcz AD, Ujvári K, Környei Z, Tóth K, Szabadits E, Sperlágh B, Baranyi M, Csiba L, Hortobágyi T, Maglóczky Z, Martinecz B, Szabó G, Erdélyi F, Szipőcs R, Tamkun MM, Gesierich B, Duering M, Katona I, Liesz A, Tamás G, Dénes Á. Cserép C, et al. Science. 2020 Jan 31;367(6477):528-537. doi: 10.1126/science.aax6752. Epub 2019 Dec 12. Science. 2020. PMID: 31831638

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Publication types