Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Jan 31;367(6477):512-513.
doi: 10.1126/science.aaz6695.

Unpicking the proteome in single cells

Affiliations

Unpicking the proteome in single cells

Nikolai Slavov. Science. .
No abstract available

PubMed Disclaimer

Figures

Figure
Figure. Single-cell protein analysis
Traditional methods identify and quantify a limited number of proteins based on antibodies barcoded with DNA sequences, fluorophores, or transition metals. Emerging single-cell mass-spectrometry (MS) methods will allow high-throughput analysis of proteins and their posttranslational modifications, interactions, and degradation.

References

    1. Sabatini DM, Proc. Natl. Acad. Sci. U.S.A 114, 11818 (2017). - PMC - PubMed
    1. Franks A, Airoldi E, Slavov N, PLOS Comput. Biol 13, e1005535 (2017). - PMC - PubMed
    1. Liu Y, Beyer A, Aebersold R, Cell 165, 535 (2016). - PubMed
    1. Segel M et al., Nature 573, 130 (2019). - PMC - PubMed
    1. Cote AJ et al., Nat. Commun 7, 10865 (2016). - PMC - PubMed

Publication types