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. 2019 Aug 31;12(2):2117.
doi: 10.4022/jafib.2117. eCollection 2019 Aug-Sep.

Relationship of Atrial Fibrillation to Outcomes in Patients Hospitalized for Chronic Obstructive Pulmonary Disease Exacerbation

Abdullah Sayied Abdullah  1 , George Eigbire  2 , Mohamed Ali  3 , Mohanad Awadalla  4 , Abdul Wahab  5 , Hisham Ibrahim  6 , Amr Salama  5 , Richard Alweis  5   7   8
Affiliations

Relationship of Atrial Fibrillation to Outcomes in Patients Hospitalized for Chronic Obstructive Pulmonary Disease Exacerbation

Abdullah Sayied Abdullah et al. J Atr Fibrillation. .

Abstract

Introduction: Chronic Obstructive Pulmonary Disease (COPD) is a major cause of hospitalization and is associated with an increased incidence of atrial fibrillation (AF). The impact of AF on in-hospital outcomes, including mortality, in patients hospitalized for COPD exacerbation is not well elucidated.

Methods: We used the National Inpatient Sample database to examine discharges with the primary diagnosis of COPD exacerbation and compared mortality, length of stay and costs in patients with AF compared to those without AF. The study adjusted the outcomes for known cardiovascular risk factors and confounders using logistic regression and propensity score matching analysis.

Results: Among 1,377,795 discharges with COPD exacerbation, 16.6% had AF. Patients with AF were older and had more comorbidities. Mortality was higher (2.4%) in the AF group than in the no AF group (1%), p <0.001. After adjustment to age, sex and confounders, AF remained an independent predictor for mortality, OR:1.44 (95% CI 133 - 1.56, p <0.001), prolonged length of stay, OR:1.63 (95% CI 1.57 - 1.69, p <0.001) and increased cost, OR: 1.45 (95% CI: 1.40 - 1.49, p <0.001).

Conclusions: among patients with COPD exacerbation, AF was associated with increased mortality and higher resource utilization.

Keywords: Arrhythmia; Atrial fibrillation; COPD; Chronic Obstructive Lung Disease; ICD code; In-hospital mortality; National Inpatient Sample.

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References

    1. Curkendall Suellen M, DeLuise Cynthia, Jones Judith K, Lanes Stephan, Stang Mary Rose, Goehring Earl, She Dewei. Cardiovascular disease in patients with chronic obstructive pulmonary disease, Saskatchewan Canada cardiovascular disease in COPD patients. Ann Epidemiol. 2006 Jan;16 (1):63–70. - PubMed
    1. Konecny Tomas, Park Jae Yoon, Somers Kiran R, Konecny Dana, Orban Marek, Soucek Filip, Parker Kenneth O, Scanlon Paul D, Asirvatham Samuel J, Brady Peter A, Rihal Charanjit S. Relation of chronic obstructive pulmonary disease to atrial and ventricular arrhythmias. Am. J. Cardiol. 2014 Jul 15;114 (2):272–7. - PubMed
    1. Liao Kuang-Ming, Chen Chung-Yu. Incidence and risk factors of atrial fibrillation in Asian COPD patients. Int J Chron Obstruct Pulmon Dis. 2017;12 ():2523–2530. - PMC - PubMed
    1. Schneider Cornelia, Bothner Ulrich, Jick Susan S, Meier Christoph R. Chronic obstructive pulmonary disease and the risk of cardiovascular diseases. Eur. J. Epidemiol. 2010 Apr;25 (4):253–60. - PubMed
    1. Johnson Linda S B, Juhlin Tord, Engström Gunnar, Nilsson Peter M. Reduced forced expiratory volume is associated with increased incidence of atrial fibrillation: the Malmo Preventive Project. Europace. 2014 Feb;16 (2):182–8. - PubMed

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