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. 1988 Oct 17;92(3):265-9.
doi: 10.1016/0304-3940(88)90600-3.

Activators of protein kinase C and phenylephrine depolarize the astrocyte membrane by reducing the K+ permeability

K E Akerman  1 , M O Enkvist, I Holopainen
Affiliations

Activators of protein kinase C and phenylephrine depolarize the astrocyte membrane by reducing the K+ permeability

K E Akerman et al. Neurosci Lett. .

Abstract

The membrane potential of astrocytes has been measured by monitoring the absorbance of a cyanine dye DiS-C2-(5). Ba2+, the phorbol ester 12-tetradecanoylphorbol myristateacetate (TPA) and the diglyceride, dioctanoylglycerol (DiC8) depolarize the membrane. Valinomycin which makes the membrane potential dependent on the K+ electrochemical potential evokes a hyperpolarization when added subsequently. The alpha-adrenergic receptor agonist phenylephrine was blocked by Ba2+, TPA, DiC8 and valinomycin. The results suggest that a protein kinase C-mediated reduction in the K+ permeability is responsible for the depolarizing effect of TPA, DiC8 and phenylephrine.

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