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Editorial
. 2020 Jan 31;105(2):257-259.
doi: 10.3324/haematol.2019.238816. Print 2020.

Insights into the composition of stroke thrombi: heterogeneity and distinct clot areas impact treatment

Rui-Gang Xu  1 , Robert A S Ariëns  1
Affiliations
Editorial

Insights into the composition of stroke thrombi: heterogeneity and distinct clot areas impact treatment

Rui-Gang Xu et al. Haematologica. .
No abstract available

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Figures

Figure 1.
Figure 1.
Schematic representation of the composition and organization of ischemic stroke thrombi as reported by Staessens et al. (Top) Red blood cell (RBC) rich area. This area mainly consists of packed RBC (polyhedrocytes) surrounded by thin fibrin fibers, which fill (or ‘cement’) the space between cells. Leukocytes (neutrophils) are also observed in these areas, but are less abundant. (Bottom) Plateletrich area. Multiple structural components are found in this area, including platelets, thick fibrin bundles, von Willebrand factor (vWF), leukocytes (neutrophils) and extracellular DNA (due to NETosis).
See this image and copyright information in PMC

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References

    1. Undas A, Ariëns RA. Fibrin clot structure and function: a role in the pathophysiology of arterial and venous thromboembolic diseases. Arterioscler Thromb Vasc Biol. 2011;31(12):e88–e99. - PubMed
    1. Sumaya W, Wallentin L, James SK, et al. Fibrin clot properties inde pendently predict adverse clinical outcome following acute coronary syndrome: a PLATO substudy. Eur Heart J. 2018;39(13):1078–1085. - PMC - PubMed
    1. Siudut J, Świat M, Undas A. Altered fibrin clot properties in patients with cerebral venous sinus thrombosis: association with the risk of recurrence. Stroke. 2015;46(9):2665–2668. - PubMed
    1. Weisel J, Litvinov R. Red blood cells: the forgotten player in hemostasis and thrombosis. J Thromb Haemost. 2019;17(2):271–282. - PMC - PubMed
    1. Martinod K, Wagner DD. Thrombosis: tangled up in NETs. Blood. 2014;123(18):2768–2776. - PMC - PubMed